Chking And executing cell division to prevent genomic instability

p53 coordinates base excision repair to prevent genomic instability

DNA constantly undergoes chemical modification due to endogenous and exogenous mutagens. The DNA base excision repair (BER) pathway is the frontline mechanism handling the majority of these lesions, and primarily involves a DNA incision and subsequent resealing step. It is imperative that these processes are extremely well-coordinated as unrepaired DNA single strand breaks (SSBs) can be convert...

Cancer: Cell Structures, Carcinogens and Genomic Instability

breast cancer and paradigm of genomic instability

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Fake Emulation Environment to Prevent Malware from Executing

Today’s malware contains sophisticated analysis countermeasures to protect itself against reverse engineering. Countermeasures fall into two categories: offline and runtime. Encryption and obfuscation of binaries are widely used offline protections. Therefore today, most analysis is done during runtime and so malware authors implement runtime countermeasures. Runtime countermeasures include ant...

Malaria-Induced B Cell Genomic Instability

Nussenzweig and colleagues evaluate genomic instability and germinal center derived lymphomagenesis in mice infected with Plasmodium to recreate some of the hallmark characteristics of Burkitt lymphoma, a form of cancer more common in parts of Africa where malaria is endemic.